Patient demographics, such as age and sex, along with the existence or lack of comorbidities and the course of the disease, were part of the medical history data that was analyzed. The visual analog scale (VAS) was employed to quantify the pain level experienced by two groups at time points T0 (pre-treatment), T1 (post-single treatment), T2 (post-double treatment), T3 (post-triple treatment), and T4 (post-quadruple treatment). The Pittsburgh Sleep Quality Index (PSQI) was applied to examine the sleep state, both before and after the study period.
General conditions within the control and observation groups showed no appreciable difference, as indicated by a p-value greater than 0.005. A decrease in VAS scores, occurring over time, was observed in both the control and observation groups following 1 to 4 weeks of treatment. Following one or two weeks of treatment, VAS scores exhibited no substantial divergence between the treatment groups (p > 0.05). After three and four weeks of treatment, a statistically significant (p < 0.0001) drop in VAS scores occurred in the observation group relative to the control group. Statistically significant reductions in VAS scores (after treatment minus before treatment) were observed in the two groups, demonstrating a D value of -153 with a 95% confidence interval of -232 to 0.074, and p < 0.0001. In addition, sleep states showed notable improvement in both groups, and this improvement was significantly greater in the observation group compared to the control group (p < 0.005).
The data collected indicate that the inclusion of acupuncture on fascia, meridians, and nerves, concurrent with ultrasound-guided PVB treatment, leads to a more effective outcome than solely relying on ultrasound-guided PVB treatment.
Registered within the Chinese Clinical Trial Registry, we find the trial identifier ChiCTR2200057955.
The Chinese Clinical Trial Registry lists the trial ChiCTR2200057955.
To assess the efficacy of cycling therapy combined with electroacupuncture in managing post-stroke hemiplegia patients at the National Hospital of Acupuncture in Vietnam.
A single-centre, parallel-group, randomized, controlled trial with blinded outcome assessment was conducted on 120 post-stroke hemiplegia patients. They were randomly divided into two groups: one receiving electroacupuncture and cycling (CT group), and the other receiving electroacupuncture alone (AT group). Patients' conditions were evaluated both pre- and post-treatment, utilizing muscle grading, the modified Rankin scale, the Barthel index, Orgorozo scores, and electromyography. A statistical analysis of the CT and AT groups was performed using the Mann-Whitney U test and Fisher's exact test.
Patients with hemiplegia experienced a statistically significant improvement in motor function following ischemic stroke, as documented in both the CT and AT groups. salivary gland biopsy Patients assigned to the CT group exhibited a more pronounced recovery trajectory than those in the AT group, characterized by enhanced muscle contraction (demonstrated by increased electromyography frequency and amplitude, and a higher muscle grading score); improved recovery (as indicated by an enhanced Orgogozo scale); increased independence (as measured by a higher Barthel index); and a reduction in disability (reflected by a lower Modified Rankin score) (p < 0.001).
The integration of cycling training with electroacupuncture treatment substantially enhances the recovery of patients who have suffered a stroke.
Electroacupuncture's efficacy in post-stroke recovery is significantly augmented by concurrent cycling training.
Exploring the potential of Xiaoyao capsule to enhance sleep and mood recovery following a diagnosis of coronavirus disease 2019 (COVID-19).
The study involved 200 patients recovering from COVID-19, who also presented with sleep and mood disorders. Patients were randomized into control and experimental groups, with blocked randomization, in the ratio of 11:1. Both the experimental and control groups of patients received either Xiaoyao capsules or a placebo Xiaoyao capsule for a period of two weeks, with the experimental group receiving the actual medication. Across the two intervention groups, an evaluation was undertaken to determine differences in Traditional Chinese Medicine (TCM) syndrome scale improvements, treatment efficacy, and the reduction of irritability, anxiety, and sleep impairment.
Treatment effects on TCM syndrome pattern scales, overall effectiveness, and improvements in irritability, anxiety, and sleep quality were not statistically different between the experimental and control groups, as determined by both the complete and per-protocol datasets, at one and two weeks post-intervention (> 0.005).
No discernible improvement in sleep and mood disorders was noted in COVID-19 recovery patients treated with Xiaoyao capsules.
No notable improvement in sleep and mood disorders was observed in COVID-19 convalescent patients treated with Xiaoyao capsules.
Evaluating the efficacy of Yikang scalp acupuncture, utilizing Baihui (GV20), Sishencong (EX-HN1), Zhisanzhen, and Niesanzhen acupoints, to enhance neurobehavioral outcomes in young rats with cerebral palsy, while considering the Notch signaling pathway's influence.
The thirty 7-day-old rats were randomly categorized into three groups, sham, model, and acupuncture, each group consisting of ten animals. The acupuncture group initiated intervention on the cerebral palsy model (established using the accepted modeling method) at 24 hours, targeting Baihui (GV20), Sishencong (EX-HN1), Zhisanzhen, and Niesanzhen. The treatment's impact on body mass was assessed by recording weights prior to and following the procedure. The rats, having undergone the intervention, were then engaged in experiments for suspension, slope, tactile stimulation, and the Morris water maze. Post-experimental analysis, the hippocampal tissue's morphological modifications were assessed via hematoxylin and eosin (H&E) staining under a light microscope, and the expression of Notch1, Notch3, and Hes5 proteins was examined using Western blot and quantitative real-time polymerase chain reaction (qRT-PCR).
The body mass of rats varied significantly across the groups; behavioral experiments showed a shortened suspension time for the model group compared to the sham, while the slope experiment, tactile stimulation test, and escape latency were prolonged. The number of platform crossings was decreased. Conversely, acupuncture treatment resulted in a longer suspension time, shorter durations for slope experiments, tactile stimulation experiments, and escape latency, and a greater number of platform crossings compared to the model group. HE staining revealed pronounced hippocampal damage in the model group and reduced hippocampal damage in the acupuncture group. FUT-175 mw Western blot and real-time fluorescence quantitative PCR analyses indicated elevated Notch1, Notch3, and Hes5 expression in the model group, contrasting with a reduction in Notch1, Notch3, and Hes5 expression following acupuncture.
The neurobehavioral outcome and brain injury reduction observed in rats with cerebral palsy, treated with Yikang therapy's scalp acupuncture, may be a result of downregulation in the expression of Notch1, Notch3, and Hes5.
In rats with cerebral palsy, scalp acupuncture Yikang therapy may potentially mitigate brain injury and improve neurobehavior, possibly by reducing the expression of Notch1, Notch3, and Hes5.
By examining acupuncture's impact on glial cell differentiation and glial scar repair, we aim to uncover the fundamental mechanism of nerve repair it facilitates.
Sprague-Dawley rats were randomly assigned to three distinct groups: the normal group, the model group, and the acupuncture group. A course of acupuncture, once daily for four weeks, targeting Renzhong (GV26), Baihui (GV20), Fengfu (GV16), Yamen (GV15), and Hegu (LI4), began within 12 hours of the creation of the TBI model. The protocol for evaluating traumatic brain injury (TBI) included neurobehavioral assessment, hematoxylin and eosin staining, immunofluorescence detection, and magnetic resonance imaging scanning on days 3, 7, 14, and 28 after modeling.
Initially, acupuncture encouraged the growth of glial cells and associated scars, but subsequently, it limited their increase in later development. A comparison of the acupuncture group and the model group, through the lens of morphological observations and immunofluorescence histochemistry, showed a structural enhancement in the perilesional cortex and an increase in the neuron count in the former. immune deficiency At days 7, 14, and 28 post-TBI modeling, the acupuncture group exhibited a smaller volume of ipsilateral brain parenchyma lesions compared to the model group, a statistically significant difference (p < 0.005).
Acupuncture's regulatory influence on glial scar repair after a traumatic brain injury (TBI) might operate in both directions. It could stimulate glial cell proliferation and glial scar formation to contain the injured area and alleviate nerve damage during the initial phase. Conversely, during the later stages, it could inhibit the overgrowth of glial scars, facilitating neuronal and axonal regeneration, and consequently enhancing neurological function recovery.
The process of glial scar repair after a TBI might be influenced in a dual manner by acupuncture, prompting the growth of glial cells and scars initially to contain the affected area and ease nerve damage, while subsequently preventing overgrowth of the glial scars to aid in neuronal and axon regeneration and thus enhance neurological function recovery.
An investigation into the effectiveness and underlying processes of electroacupuncture at Zusanli (ST36) on skeletal muscle injury caused by repeated jumping is undertaken.
Female Sprague-Dawley rats, six per group, were randomly divided into four groups in this investigation: a normal control group, a jumping-induced muscle injury group, a jumping-induced muscle injury group receiving electroacupuncture, and a jumping-induced muscle injury group receiving non-electroacupuncture stimulation. The gastrocnemius muscle of the ipsilateral lower limbs was subjected to a battery of analyses, including transmission electron microscopy, transcriptome sequencing and analysis, prediction of protein interaction networks, real-time polymerase chain reaction verification, and Western blotting.